Thionyl Chloride → 2-(Chloromethyl)-1-methylbenzimidazole

Beteiligte Stoffe

Reaktionsschritte

A solution of (1-methyl-1H-benzoimidazol-2-yl)-methanol (500 mg, 3.08 mmol) and SOCl2 (1.1 mL) in DCM (2 mL) was stirred at room temperature for 3 hours. After evaporation of the solvents, 2-chloromethyl-1-methyl-1H-benzoimidazole (556 mg, 3.08 mmol) was obtained and was used without any purification.

Herkunft & Nachweise