Sodium Azide → HCID 178505536, Verbindung
Reaktionsgleichung
[N-:1]=[N+:2]=[N-:3].[Na+].[F:5][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[N+]([O-])=O)=[CH:8][CH:7]=1>CS(C)=O>[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:1]=[N:2][NH:3][CH:13]=2)=[CH:8][CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Sodium azide (4.28 g, 65.8 mmol) was added to a solution (E)-1-fluoro-4-(2-nitro-vinyl)-benzene (1.00 g, 5.98 mmol) in DMSO (50 mL), the solution was stirred at room temperature for 14 hours and the reaction mixture was poured onto water. The aqueous phase was extracted with AcOEt. The organic phase was washed with saturated solution of NaHCO3, brine, dried over MgSO4, filtered and evaporated to yield 300 mg (1.84 mmol, 31%) of 4-(4-fluoro-phenyl)-1H-[1,2,3]triazole.
Aufarbeitung
- additionthe reaction mixture was poured onto water
- extractionThe aqueous phase was extracted with AcOEt
- washThe organic phase was washed with saturated solution of NaHCO3, brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-f67b3445bb81477ab414b3415c2d6b90
- Quelldatensatz
- uspto-grants-2014_11
- Patentnummer
- US08883826B2
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