Propanal → HCID 66995125, Verbindung

HRID 335137

Reaktionsgleichung

Reaktionsgleichung von HRID 335137
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

Komponenten

5

Edukt 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

Produkt 1

HCID 66995125HCID 66995125, VerbindungAusbeute 225 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customchromatographed

Quellen und Nachweise

ORD-Eintrag
ord-97d920ad523d4714be8f46d5b7eae3d2
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883828B2

Verknüpfte Notizen

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