2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide → 1-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine

HRID 335475

Reaktionsgleichung

Reaktionsgleichung von HRID 335475
[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][NH2:16])=[O:14])[CH3:2]>CO>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][N:16]=[CH:1][CH:3]([CH3:8])[CH3:4])=[O:14])[CH3:2]

Komponenten

3

Edukt 1

HCID 569428732-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide

Produkt 1

HCID 682980701-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazineAusbeute 188,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a 300 mL volume three-necked flask, 20.0 g of 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetohydrazide ((12-1)-(11)-39), 76 ml of methanol and 12.3 g of isobutylaldehyde were added and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated under reduced pressure and then hexane was added thereto. The precipitated crystals were collected by filtration and dried under reduced pressure to give 23.2 g of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine ((40-a)-(14)-4).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionhexane was added
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5881e2f4d94b4233b9959bc5775ceb86
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08884010B2

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