Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylate → Methyl thieno[2,3-b]pyridine-2-carboxylate

HRID 335549

Reaktionsgleichung

Reaktionsgleichung von HRID 335549
N[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[C:11]([O:13][CH3:14])=[O:12].N([O-])=O.[Na+]>>[S:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[CH:2]=[C:3]1[C:11]([O:13][CH3:14])=[O:12]

Komponenten

3

Edukt 2

HCID 2820896Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylateHCID 23668193Sodium Nitrite

Produkt 1

HCID 19007380Methyl thieno[2,3-b]pyridine-2-carboxylate

Versuchsvorschrift

The synthesis is carried out according to the general procedure; for work-up, the resulting precipitate is filtered off with suction and washed twice with water and three times with ethyl acetate. The organic phase of the resulting filtrate is separated off, dried and concentrated. Using 0.22 g (1.07 mmol) of methyl 3-aminothieno[2,3-b]pyridine-2-carboxylate and 0.24 g (3.41 mmol) of sodium nitrite, 84 mg (41% of theory) of the desired product are obtained.

Aufarbeitung

  1. filtrationfor work-up, the resulting precipitate is filtered off with suction
  2. washwashed twice with water and three times with ethyl acetate
  3. customThe organic phase of the resulting filtrate is separated off
  4. customdried
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-92f59be139a640f8ab07e658d0a01b79
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08884017B2

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