Methyl Thioglycolate → 6-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester

HRID 335557

Reaktionsgleichung

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[C:4](F)[CH:3]=1.[H-].[Na+].[SH:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]2[CH:6]=[C:14]([C:15]([O:17][CH3:18])=[O:16])[S:13][C:4]=2[CH:3]=1

Komponenten

Edukt 3

HCID 16907Methyl Thioglycolate

HCID 24758Sodium hydride

HCID 1435174-Bromo-2-fluorobenzaldehyde

Produkt 1

HCID 224740786-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester

Versuchsvorschrift

Using 6.54 g (32.2 mmol) of 4-bromo-2-fluorobenzaldehyde, 1.93 g (48.3 mmol) of sodium hydride (60% pure) and 3.76 g (35.5 mmol) of methyl mercaptoacetate, 4.06 g (46.4% of theory) of the title compound are obtained.

Quellen und Nachweise

ORD-Eintrag: ord-b41f8ecb5dac403bbe136c6476ee65e7
Quelldatensatz: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08884017B2

Verknüpfte Notizen

Wird geladen…