Phosgene → HCID 58355784, Verbindung

HRID 336039Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 336039
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([OH:14])([CH3:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15](Cl)([Cl:17])=[O:16]>C1COCC1.C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][C:10]([O:14][C:15]([Cl:17])=[O:16])([CH3:13])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 2

HCID 6371PhosgeneHCID 22951485tert-Butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate

Produkt 1

HCID 58355784HCID 58355784, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 3-hydroxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester (200 mg, 1.00 mmol) in THF (4 mL) was slowly treated with phosgene 20% in toluene (0.954 mL). After stirring at rt for 16 h, solvents were removed under reduced pressure and co-evaporate with CH2Cl2. The crude 3-chlorocarbonyloxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester was used directly in the next step.

Aufarbeitung

  1. customsolvents were removed under reduced pressure and co-evaporate with CH2Cl2

Quellen und Nachweise

ORD-Eintrag
ord-91c2ab9a71984d2c8bbf43b1e2e42bc9
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08884030B2

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