Hydrochloric Acid → (S)-Perhydro-azepine-2-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide hydrochloride

HRID 336216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 336216
[ClH:1].C(OC([N:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[C:16](=[O:27])[NH:17][C:18]1[CH:22]=[C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])[O:20][N:19]=1)=O)(C)(C)C>O1CCOCC1.C(Cl)Cl>[ClH:1].[C:23]([C:21]1[O:20][N:19]=[C:18]([NH:17][C:16]([C@@H:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:9]2)=[O:27])[CH:22]=1)([CH3:26])([CH3:24])[CH3:25]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 58563977(S)-2-(5-tert-Butyl-isoxazol-3-ylcarbamoyl)-perhydro-azepine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 86660403(S)-Perhydro-azepine-2-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

HCl in dioxane (10.0 mL) is added slowly at 0° C. to a solution of (S)-2-(5-tert-butyl-isoxazol-3-ylcarbamoyl)-perhydro-azepine-1-carboxylic acid tert-butyl ester (0.70 g, 1.90 mmol) in DCM (15.0 mL). After stirring the reaction mixture at 0° C. for 3 hours, the solvent is removed under reduced pressure to afford the title product that is used in the next step without further purification.

Aufarbeitung

  1. customthe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7bbcfb5178c749599c07db71e04a255f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889670B2

Notizen zur Reaktion

Wird geladen…