Oxalyl chloride → 1-{4-[3-(5-Fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-5-YL]-2-nitrophenyl}-2-methylpiperidine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Oxalyl chloride	HCID 65578	—
Edukt	Diisopropylethylamine	HCID 81531	—
Edukt	4-(2-Methylpiperidin-1-yl)-3-nitrobenzoic acid	HCID 43176702	—
Edukt	5-fluoro-N'-hydroxy-2-methoxybenzenecarboximidamide	HCID 72336823	—
Produkt	1-{4-[3-(5-Fluoro-2-methoxyphenyl)-1,2,4-oxadiazol-5-YL]-2-nitrophenyl}-2-methylpiperidine	HCID 25256387	—

Reaktionsschritte

Oxalyl chloride (190 mg; 1.5 mmol; 3 eq.), Intermediate 8 (132 mg; 0.5 mmol; 1 eq.), Intermediate 23 (92 mg; 0.5 mmol, 1 eq.) and DIEA (194 mg; 1.5 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography (c-hexane/ethyl acetate, 80/20) followed by crystallisation from ethyl acetate/n-pentane afforded the title compound as a yellow solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08889668B2
Quelldatensatz	uspto-grants-2014_11
ORD ID	ord-7c71984599a14d8bb4b796c40571eb43
Quellennotiz	uspto-grants-2014_11