Methanol → 3-Bromotricyclo[3.3.1.13,7]decane-1-methanol

HRID 336582

Reaktionsgleichung

Reaktionsgleichung von HRID 336582
O1CCCC1.B.CO.[Br:9][C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([C:20](O)=[O:21])([CH2:13]3)[CH2:11]1)[CH2:17]2>O1CCCC1>[Br:9][C:10]12[CH2:19][CH:14]3[CH2:15][CH:16]([CH2:18][C:12]([CH2:20][OH:21])([CH2:13]3)[CH2:11]1)[CH2:17]2

Komponenten

5

Edukt 3

HCID 887MethanolHCID 308183-Bromoadamantane-1-carboxylic acidHCID 2723981Borane;tetrahydrofuran

Produkt 1

HCID 28029653-Bromotricyclo[3.3.1.13,7]decane-1-methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

In a 250 ml round-bottomed flask, 3-bromoadamantane-1-carboxylic acid (7.89 g) was dissolved in tetrahydrofuran (30 mL). Borane tetrahydrofuran complex (1M in hexane, 60 mL) was added slowly. The mixture was stirred at room temperature overnight. Methanol (20 mL) was added to the solution slowly. After removal of the solvents, methanol (5 mL) was added to the oily residue. Removal of the solvent provided the title compound.

Aufarbeitung

  1. customAfter removal of the solvents, methanol (5 mL)
  2. additionwas added to the oily residue
  3. customRemoval of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-2fef7fb5ad81442a8b70465b243a5d5d
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889675B2

Verknüpfte Notizen

Wird geladen…