Acetic acid, 2-(4-formylphenoxy)- → 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid

HRID 336671

Reaktionsgleichung

Reaktionsgleichung von HRID 336671
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([O:13][CH3:14])[C:3]=1[C:4]([NH2:6])=[O:5].[CH:15]([C:17]1[CH:27]=[CH:26][C:20]([O:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:19][CH:18]=1)=O.OC1C=CC(C2NC(=O)C3C(=CC(OC)=CC=3OC)N=2)=CC=1>>[CH3:14][O:13][C:7]1[CH:8]=[C:9]([O:11][CH3:12])[CH:10]=[C:2]2[C:3]=1[C:4](=[O:5])[NH:6][C:15]([C:17]1[CH:27]=[CH:26][C:20]([O:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:19][CH:18]=1)=[N:1]2

Komponenten

4

Edukt 3

HCID 89177Acetic acid, 2-(4-formylphenoxy)-HCID 203490162-Amino-4,6-dimethoxybenzamideHCID 1360380002-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Produkt 1

HCID 1360380182-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acidAusbeute 21 %

Versuchsvorschrift

2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid was synthesized from 2-amino-4,6-dimethoxy-benzamide and (4-formyl phenoxy)acetic acid, using the method described for 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one. 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid (135 mg, 21%) was isolated as an off-white solid. Selected data: MS (m/z): 357.04; MP 287-290° C.

Quellen und Nachweise

ORD-Eintrag
ord-03dd7199c00e40c0a0cce95de127152e
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889698B2

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