Triethyl Phosphate → Allyl(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

HRID 336924

Reaktionsgleichung

Reaktionsgleichung von HRID 336924
P(OCC)(OCC)(OCC)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[CH:26]([C:28]1[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][C:29]=1[S:36]([CH3:39])(=[O:38])=[O:37])=O.[F:40][C:41]([F:53])([F:52])[C:42]1[CH:43]=[C:44]([NH:48][C:49]([NH2:51])=[O:50])[CH:45]=[CH:46][CH:47]=1.[C:54]([O:60][CH2:61][CH:62]=[CH2:63])(=[O:59])[CH2:55][C:56]([CH3:58])=O>CC(OC)(C)C>[C:32]([C:31]1[CH:34]=[CH:35][C:28]([CH:26]2[C:55]([C:54]([O:60][CH2:61][CH:62]=[CH2:63])=[O:59])=[C:56]([CH3:58])[N:48]([C:44]3[CH:45]=[CH:46][CH:47]=[C:42]([C:41]([F:52])([F:53])[F:40])[CH:43]=3)[C:49](=[O:50])[NH:51]2)=[C:29]([S:36]([CH3:39])(=[O:38])=[O:37])[CH:30]=1)#[N:33]

Komponenten

7

Edukt 5

HCID 6535Triethyl PhosphateHCID 14812Phosphorus oxide (P4O10)HCID 25712(3-Trifluoromethylphenyl)ureaHCID 70701Allyl acetoacetateHCID 581337504-Formyl-3-(methylsulfonyl)benzonitrile

Produkt 1

HCID 42642358Allyl(rac)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 15413tert-Butyl methyl etherLösungsmittel

Versuchsvorschrift

The reaction was carried out under argon. Triethyl phosphate (22.98 g, 126 mmol) and diphosphorus pentoxide (11.94 g, 84.1 mmol) were stirred at 50° C. overnight. The mixture was then diluted with MTBE (450 ml), and 4-formyl-3-(methylsulfonyl)benzonitrile (22.00 g, 105 mmol; Example 4A), 1-[3-(trifluoromethyl)phenyl]urea (21.47 g, 105 mmol) and allyl acetoacetate (22.42 g, 158 mmol) were added. The mixture was stirred under reflux overnight. Since the reaction was incomplete, the reaction mixture was concentrated by distillative removal of 350 ml of MTBE. The mixture was then heated under reflux for a further 4 h. For work-up, the solvent was removed under reduced pressure, and the residue was suspended in diethyl ether and then filtered off with suction. The solid was washed with dist. water (350 ml) and then with diethyl ether (50 ml). This gave 34.74 g (64% of theory) of the title compound.

Aufarbeitung

  1. additionwere added
  2. temperatureunder reflux overnight
  3. concentrationthe reaction mixture was concentrated by distillative removal of 350 ml of MTBE
  4. temperatureThe mixture was then heated
  5. temperatureunder reflux for a further 4 h
  6. customFor work-up, the solvent was removed under reduced pressure
  7. filtrationfiltered off with suction
  8. washThe solid was washed with dist

Quellen und Nachweise

ORD-Eintrag
ord-02871a5d176d4231957fb565b166b82b
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889700B2

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