Ammonia → 2-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

HRID 337069

Reaktionsgleichung

Reaktionsgleichung von HRID 337069
[CH3:1][C:2]1([CH3:12])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:11].[NH3:13]>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:2]([CH3:12])([CH3:1])[C:3]([NH2:13])=[O:11]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 5956202(3H)-Benzofuranone, 3,3-dimethyl-

Produkt 1

HCID 866632482-Hydroxy-alpha,alpha-dimethyl-benzeneacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

3,3-Dimethylbenzofuran-2(3H)-one (Example 198a, 19.7 g) was dissolved in 7N ammonia in methanol (50 mL) under nitrogen. The resulting solution was stirred at 25° C. for 16 h. The reaction mixture was evaporated to afford crude product. The solid was triturated with diethyl ether and filtered to give the subtitle compound (15.34 g).

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. customto afford crude product
  3. customThe solid was triturated with diethyl ether
  4. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-8158e9f3f7074379993b11da7f2de2d8
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889692B2

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