Hydrochloric Acid → (RS)-2-bromo-6-(1-hydroxyheptyl)anisole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).

Herkunft & Nachweise