3-Fluoropentane-2,4-dione → 1-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazole

HRID 337353Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 337353
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][NH2:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:18][CH:19]([C:23](=O)[CH3:24])[C:20](=O)[CH3:21]>C(O)C>[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]1[C:23]([CH3:24])=[C:19]([F:18])[C:20]([CH3:21])=[N:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 116266523-Fluoropentane-2,4-dioneHCID 12891836(2-(Benzyloxy)phenyl)hydrazine hydrochloride

Produkt 1

HCID 867032601-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazoleAusbeute 70,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

500 mg of 2-benzyloxyphenyl hydrazine hydrochloride and 251 mg of 3-fluoropentane-2,4-dione were added to 12 ml of ethanol, and heated at reflux for 1.5 hours. The reaction solution was concentrated under reduced pressure as it is and purified using silica gel column chromatography (hexane:ethyl acetate=6:1 to 5:1) to yield 417 mg of the title compound.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 1.5 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure as it
  4. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-88a8dce911be426ba17e9c018908fdd3
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889727B2

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