5-(hydrazinecarbonyl)-N-(pyridine-4-ylmethyl)thiophene-2-carboxamide → HCID 86669400, Verbindung
Reaktionsgleichung
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]3[N:14]([CH3:15])[N:13]=[C:12]([C:16](=O)[CH3:17])[C:11]=3[OH:19])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH:20]([C:22]([C:24]1[S:28][C:27]([C:29]([NH:31][CH2:32][C:33]2[CH:38]=[CH:37][N:36]=[CH:35][CH:34]=2)=[O:30])=[CH:26][CH:25]=1)=[O:23])[NH2:21]>CS(C)=O>[CH2:1]1[C:9]2[C:4](=[CH:5][C:6]([C:10]3[N:14]([CH3:15])[N:13]=[C:12]([C:16](=[N:21][NH:20][C:22]([C:24]4[S:28][C:27]([C:29]([NH:31][CH2:32][C:33]5[CH:34]=[CH:35][N:36]=[CH:37][CH:38]=5)=[O:30])=[CH:26][CH:25]=4)=[O:23])[CH3:17])[C:11]=3[OH:19])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
1-[5-(2,3-Dihydro-1H-inden-5-yl)-4-hydroxy-1-methyl-1H-pyrazol-3-yl]ethanone (30 mg, 0.117 mmol) and 5-(hydrazinecarbonyl)-N-(pyridine-4-ylmethyl)thiophene-2-carboxamide (32 mg, 0.117 mmol, synthesized in accordance with WO2007010954) in dimethyl sulfoxide (0.9 mL) was heated at 100° C. for 3 days with stirring. After the reaction, the reaction solution was concentrated under reduced pressure. After addition of chloroform and ethyl acetate, the resulting crystals were collected by filtration and dried under reduced pressure to obtain the desired product (44 mg, 73% yield).