HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 33749Erstellt: 23. Oktober 2026
Lawesson's reagent → (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione
https://huagongshe.com/de/reaction/33749
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Lawesson's reagent | HCID 87949 | — |
| Edukt | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethylfuran-2-yl)-methanone | HCID 11244101 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione | HCID 11508298 | — |
Reaktionsschritte
A solution of (4-isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanone (Example 1, 1 equiv.) and Lawesson's reagent (2.1 equiv.) in THF is heated at reflux (70° C.) for 48 h. The reaction is cooled to room temperature and the solvent is removed in vacuo. Chromatography of the residue on a silica gel column using 1-6% 2 M NH3 in MeOH/DCM) provides the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07429659B2 |
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| Quelldatensatz | uspto-grants-2008_09 |
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| ORD ID | ord-1110e46f7d2f433e8f777fa8a0a330e1 |
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| Quellennotiz | uspto-grants-2008_09 |
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