Hydrochloric Acid → 4,4-Difluoro-2-(1-methyl-1H-pyrazol-5-yl)cyclohex-2-en-1-one
Reaktionsgleichung
[F:1][C:2]1([F:18])[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[C:4]([C:12]2[N:16]([CH3:17])[N:15]=[CH:14][CH:13]=2)=[CH:3]1.Cl>C1COCC1>[F:18][C:2]1([F:1])[CH2:11][CH2:10][C:5](=[O:6])[C:4]([C:12]2[N:16]([CH3:17])[N:15]=[CH:14][CH:13]=2)=[CH:3]1Komponenten
4
Versuchsvorschrift
The reaction and aftertreatment were conducted in the same manner as in Example 67c by using the 5-(8,8-difluoro-1,4-dioxaspiro[4.5]dec-6-en-6-yl)-1-methyl-1H-pyrazole (758 mg, 2.96 mmol) prepared in Example 88e, 5 M hydrochloric acid (10 mL) and THF (10 mL), to yield the title compound (170 mg, 14%, 3 steps) as a colorless oil.
Aufarbeitung
- customThe reaction and aftertreatment
Quellen und Nachweise
- ORD-Eintrag
- ord-65adacb41a534d1aa5371f869358076d
- Quelldatensatz
- uspto-grants-2014_11
- Patentnummer
- US08889741B2
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