2,4-Difluoropyrimidine → N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amine

HRID 337872

Reaktionsgleichung

Reaktionsgleichung von HRID 337872
[F:1][C:2]1[N:7]=[C:6](F)[CH:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:12]=1[CH2:13][NH2:14]>C1COCC1>[CH3:9][O:10][C:11]1[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:12]=1[CH2:13][NH:14][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([F:1])[N:7]=1

Komponenten

4

Edukt 2

HCID 1377162,4-DifluoropyrimidineHCID 5972502,4-Dimethoxybenzylamine

Produkt 1

HCID 89963279N-(2,4-dimethoxybenzyl)-2-fluoropyrimidin-4-amineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 2,4-difluoropyrimidine (1.00 g, 8.62 mmol) and 2,4-dimethoxybenzylamine (1.44 g, 8.62 mmol) in THF (28 mL) was stirred at room temperature for 1 hour. The reaction solution was vacuum concentrated, and the residue was purified with silica gel chromatography to yield the title compound (2.27 g, 62%) as a colorless amorphous solid.

Aufarbeitung

  1. concentrationconcentrated
  2. customthe residue was purified with silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8ef1271493224f55ad7ece80cb825aba
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889741B2

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