Hydrochloric Acid → 2-(4-Bromophenyl)pyrrolidine hydrochloride

HRID 338426

Reaktionsgleichung

Reaktionsgleichung von HRID 338426
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][N:9]2C(OC(C)(C)C)=O)=[CH:4][CH:3]=1.[ClH:20]>CO>[ClH:20].[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH2:12][CH2:11][CH2:10][NH:9]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 53407516tert-Butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate

Produkt 1

HCID 534075152-(4-Bromophenyl)pyrrolidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

The suspension of tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate (1.2 g, 3.7 mmol) in anhydrous methanol (10 mL) was added hydrogen chloride in methanol (20 mL, 4.0M in MeOH) under nitrogen. The reaction was stirred at room temperature for 1.5 hours. The mixture was concentrated to afford the title compound (0.99 g, quantitative yield) which was used without purification in the next step.

Aufarbeitung

  1. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-fee60a7d31904186b2bff237eb169f36
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889730B2

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