HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanol → 4-(2-Quinolin-2-yl-ethyl)-benzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | 4-(2-Quinolin-2-yl-ethyl)-benzoic acid methyl ester | HCID 68575869 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-(2-Quinolin-2-yl-ethyl)-benzoic acid | HCID 68576307 | 86% |
Reaktionsschritte
To a solution of 4-(2-Quinolin-2-yl-ethyl)-benzoic acid methyl ester (680 mg) in THF (11 ml)/methanol (3 ml) was added 1N sodium hydroxide solution (4.67 ml). The reaction mixture stirred for 4 h. and the pH adjusted to 3. The white solid was filtered to provide the title compound (550 mg, 86%). MS: (M+H m/z=278.1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07429665B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-0cc8621753b5413c8299f25a9bc3a651 |
| Quellennotiz | uspto-grants-2008_09 |