3-Bromo-4-hydroxybenzaldehyde → HCID 60194686, Verbindung

HRID 338809

Reaktionsgleichung

Reaktionsgleichung von HRID 338809
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[SH:12].[Br:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[OH:22])[CH:17]=O>CN(C=O)C>[Br:13][C:14]1[CH:15]=[C:16]([CH:17]2[NH:1][C:2]3[CH:7]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:5]=[CH:4][C:3]=3[S:12]2)[CH:19]=[CH:20][C:21]=1[OH:22]

Komponenten

4

Edukt 2

HCID 763083-Bromo-4-hydroxybenzaldehydeHCID 880422-Amino-4-(trifluoromethyl)benzenethiol

Produkt 1

HCID 60194686HCID 60194686, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

In a DMF (3 mL) solvent, a solution including 2-amino-4-trifluoromethylbenzenethiol (100 mg, 0.44 mmol) and 3-bromo-4-hydroxybenzaldehyde (88.4 mg, 0.44 mmol) was heated at a temperature of 100° C. for 2.5 hours. After DMF was evaporated, the residual was distributed between methylene chloride and water, and an organic layer was evaporated. The produced solid was filtered, and washed with ethyl acetate to obain a solid Compound 119.

Aufarbeitung

  1. customAfter DMF was evaporated
  2. customan organic layer was evaporated
  3. filtrationThe produced solid was filtered
  4. washwashed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-072af3e54f1840808a101805588a7fcc
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889881B2

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