Hydrazine → Methyl 6-hydrazinylpyridine-3-carboxylate

HRID 338847Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 338847
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[NH2:12][NH2:13]>C1COCC1>[NH:12]([C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1)[NH2:13]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 13758765Methyl 6-fluoropyridine-3-carboxylate

Produkt 1

HCID 55280209Methyl 6-hydrazinylpyridine-3-carboxylateAusbeute 89,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of methyl 6-fluoronicotinate (13.9 g, 89.60 mmol) and hydrazine (5.625 ml, 179.2 mmol) in THF (200 mL) were heated at 56° C. for 2 hours. After cooling to ambient temperature, the solvent was removed under reduced pressure and water (200 mL) was added. The suspension was stirred at ambient temperature for 1 hour. The solid was collected by filtration, washed with water and dried to give methyl 6-hydrazinylnicotinate (13.4 g, 89.5%) as a solid.

Aufarbeitung

  1. customthe solvent was removed under reduced pressure and water (200 mL)
  2. additionwas added
  3. filtrationThe solid was collected by filtration
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c937c3d86bc743d4970c90d94f93d68f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889704B2

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