tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate → tert-butyl N-[(3S)-1-[(1R)-1-[6-[(2E)-2-[(7-ethoxy-6-fluoroquinolin-2-yl)methylidene]hydrazinyl]pyridin-3-yl]-2,2,2-trifluoroethyl]pyrrolidin-3-yl]carbamate

HRID 338947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 338947
[F:1][C:2]([F:26])([F:25])[C@H:3]([N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13]1)[C:4]1[CH:5]=[N:6][C:7]([NH:10][NH2:11])=[CH:8][CH:9]=1.[CH2:27]([O:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[CH:35][C:36]([CH:40]=O)=[N:37]2)=[CH:32][C:31]=1[F:42])[CH3:28]>C(O)C>[CH2:27]([O:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[CH:35][C:36](/[CH:40]=[N:11]/[NH:10][C:7]3[N:6]=[CH:5][C:4]([C@@H:3]([N:12]4[CH2:16][CH2:15][C@H:14]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:23])[CH3:21])[CH2:13]4)[C:2]([F:25])([F:1])[F:26])=[CH:9][CH:8]=3)=[N:37]2)=[CH:32][C:31]=1[F:42])[CH3:28]

Komponenten

4

Edukt 2

HCID 86707414tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamateHCID 867074687-Ethoxy-6-fluoroquinoline-2-carbaldehyde

Produkt 1

HCID 140628984tert-butyl N-[(3S)-1-[(1R)-1-[6-[(2E)-2-[(7-ethoxy-6-fluoroquinolin-2-yl)methylidene]hydrazinyl]pyridin-3-yl]-2,2,2-trifluoroethyl]pyrrolidin-3-yl]carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(6-hydrazinylpyridin-3-yl)ethyl)pyrrolidin-3-ylcarbamate (240 mg, 0.639 mmol) and 7-ethoxy-6-fluoroquinoline-2-carbaldehyde (140 mg, 0.639 mmol) in ethanol (5 mL) were stirred at ambient temperature for 24 hours. After concentration, the residue was used in the next step without purification.

Aufarbeitung

  1. concentrationAfter concentration
  2. customthe residue was used in the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-bb48c85ad0034f028fb97feaae159c36
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889704B2

Notizen zur Reaktion

Wird geladen…