Hydrochloric Acid → Ethyl 3-amino-3-(2,5-difluorophenyl)propanoate

Acetyl chloride (4 ml) was added dropwise at room temperature to a round-bottom flask containing ethanol (50 ml). 3-Amino-3-(2,5-difluorophenyl)propionic acid (2.94 g) was added to the ethanolic hydrochloric acid solution thus prepared, and the mixture was stirred at 50° C. for three hours. Subsequently, the mixture was concentrated under reduced pressure, and the residue was admixed with 1N sodium hydroxide solution (100 ml) and extracted immediately with dichloromethane (3×50 ml). The combined organic phases were dried (Na2SO4), filtered and concentrated. The product (3.2 g) was used without further purification.

1. customthus prepared
2. concentrationSubsequently, the mixture was concentrated under reduced pressure
3. extractionextracted immediately with dichloromethane (3×50 ml)
4. dry with materialThe combined organic phases were dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customThe product (3.2 g) was used without further purification

ORD-Eintrag

ord-480882378fb641c5951efc89f0067bfa

Quelldatensatz

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08895547B2