N,N-Dimethylethylenediamine → HCID 178436936, Verbindung

HRID 340038

Reaktionsgleichung

Reaktionsgleichung von HRID 340038
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][C:13]3[NH:16][C:17]([C:19]4[C:27]5[C:22](=[CH:23][C:24]([C:28]6[CH:33]=[C:32]([F:34])[C:31]([OH:35])=[CH:30][C:29]=6[CH2:36][CH3:37])=[CH:25][CH:26]=5)[NH:21][N:20]=4)=[N:18][C:12]=3[CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH3:38][N:39]([CH3:43])[CH2:40][CH2:41][NH2:42]>>[CH3:38][N:39]([CH3:43])[CH2:40][CH2:41][NH:42][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:10]2[CH2:15][CH2:14][C:13]3[NH:16][C:17]([C:19]4[C:27]5[C:22](=[CH:23][C:24]([C:28]6[CH:33]=[C:32]([F:34])[C:31]([OH:35])=[CH:30][C:29]=6[CH2:36][CH3:37])=[CH:25][CH:26]=5)[NH:21][N:20]=4)=[N:18][C:12]=3[CH2:11]2)=[O:9])=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 66053N,N-DimethylethylenediamineHCID 178436919HCID 178436919, Verbindung

Produkt 1

HCID 178436936HCID 178436936, VerbindungAusbeute 46 %

Versuchsvorschrift

The title compound was prepared from (5-chloropyrazin-2-yl)(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (100 mg, 193 μmol) and N,N-dimethylethylendiamine, (34 mg, 386 μmol) using the method of Example 32. The crude material was purified by HPLC Method E to afford (50 mg, 46%) of the title compound as white solid.

Aufarbeitung

  1. customThe crude material was purified by HPLC Method E

Quellen und Nachweise

ORD-Eintrag
ord-894c620ceb0c4ed8bc38560457915917
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895544B2

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