HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Furancarboxylic acid → Furan-2-carboxylic acid {7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Furancarboxylic acid | HCID 6919 | — |
| Edukt | 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine | HCID 178507809 | — |
| Produkt | Furan-2-carboxylic acid {7-fluoro-1-(furan-2-carbonyl)-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazole-5-yl}-amide | HCID 59797182 | 37,9% |
Reaktionsschritte
Following amidation using 217 mg of 7-fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1H-indazol-5-ylamine and 286 mg of 2-furancarboxylic acid in accordance with the method of Example 127, purification by LC-MS was carried out, to afford 143 mg of the title compound as yellow crystals.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07429609B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-01a90d08fb0a473ea7da21d086405516 |
| Quellennotiz | uspto-grants-2008_09 |