Thionyl Chloride → HCID 86652358, Verbindung

HRID 340334Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 340334
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1.S(Cl)([Cl:31])=O>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([Cl:31])=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 58213539HCID 58213539, Verbindung

Produkt 1

HCID 86652358HCID 86652358, Verbindung

Versuchsvorschrift

A solution of 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylbenzoic acid (from the previous step) in thionyl chloride was stirred at 60° C. for 3 hour. After cooling to ambient temperature, the reaction mixture was concentrated en vacuo. The crude material was used for next step without purification.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated en vacuo
  2. customThe crude material was used for next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-611b483cfb9e44098db8337c0b78f391
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895577B2

Notizen zur Reaktion

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