Hydrochloric Acid → 1H-thieno[2,3-c]pyrazole-5-carbonitrile

HRID 34075

Reaktionsgleichung

Reaktionsgleichung von HRID 34075
C([N:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1)(=O)C.Cl>C(O)C.[OH-].[Na+]>[NH:4]1[C:8]2[S:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[N:5]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 689272371-Acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile

Produkt 1

HCID 689269941H-thieno[2,3-c]pyrazole-5-carbonitrileAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To a suspension of 215 mg of 1-acetyl-1H-thieno[2,3-c]pyrazole-5-carbonitrile in 8 mL of ethanol, 1 mL of 5N sodium hydroxide aqueous solution was added at room temperature, and stirred at this temperature for 10 minutes. Then the solution was neutralized with 5N hydrochloric acid, extracted with ethyl acetate, and the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 168 mg of the title compound as colorless crystals.

Aufarbeitung

  1. additionwas added at room temperature
  2. extractionextracted with ethyl acetate
  3. washthe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-fe2c8efc4b0447988675b250e4cc7df3
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

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