Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)- → 1H-Pyrazolo[4,3-c]pyridine

HRID 34082Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34082
[N:1]1(C(=O)C)[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1>C(O)C.[OH-].[Na+]>[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1

Komponenten

4

Edukt 1

HCID 23070130Ethanone, 1-(1H-pyrazolo[4,3-c]pyridin-1-yl)-

Produkt 1

HCID 199305001H-Pyrazolo[4,3-c]pyridineAusbeute 81,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

To a solution of 6.44 g of 1-pyrazolo[4,3-c]pyridin-1-yl-ethanone in 120 mL of ethanol, 10 mL of 5N sodium hydroxide aqueous solution was added at room temperature and stirred at this temperature for 30 minutes. After neutralization with 5N hydrochloric acid, the solvent was evaporated, the residue was washed with ethyl acetate, and the solvent of filtrate was evaporated, to afford 3.88 g of the title compound as pale yellow crystals.

Aufarbeitung

  1. customAfter neutralization with 5N hydrochloric acid, the solvent was evaporated
  2. washthe residue was washed with ethyl acetate
  3. customthe solvent of filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bc9584153d024b7d907f9748370ecf08
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429609B2

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