Hydrazine → Isoquinoline-3-carbohydrazide

HRID 340886

Reaktionsgleichung

Reaktionsgleichung von HRID 340886
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13]C)=O)[N:2]=1.[NH2:15][NH2:16]>C(O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([NH:15][NH2:16])=[O:13])[N:2]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 725374Methyl 3-isoquinolinecarboxylate

Produkt 1

HCID 55263898Isoquinoline-3-carbohydrazideAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 30 min
  2. concentrationconcentrated under high vacuum
  3. customto remove hydrazine
  4. customThe resulting residue was triturated with ethanol (20 mL)

Quellen und Nachweise

ORD-Eintrag
ord-326e316ddfb74c1f8b140e81d1113f34
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895582B2

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