HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 34091Erstellt: 24. Oktober 2026
3-(Dimethylamino)-2-propenal → 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-5-(pyrimidin-2-yl)-1H-indazole
https://huagongshe.com/de/reaction/34091
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 3-(Dimethylamino)-2-propenal | HCID 79125 | — |
| Edukt | 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxamidine Hydrochloride | HCID 68928009 | — |
| Lösungsmittel | Pyridine | HCID 1049 | — |
| Produkt | 6-Fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-5-(pyrimidin-2-yl)-1H-indazole | HCID 60034727 | — |
Reaktionsschritte
36 mg of 6-fluoro-3-[(E)-2-(4-fluorophenyl)-vinyl]-1H-indazole-5-carboxamidine hydrochloride obtained by Example 599 and 15 μl of 3-dimethylaminopropenal were dissolved in 1 mL of pyridine, and stirred at 120° C. for 7 hours. After distilling off the solvent, purification by LC-MS was conducted, to give 0.61 mg of the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07429609B2 |
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| Quelldatensatz | uspto-grants-2008_09 |
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| ORD ID | ord-eba3391fdedb4d1195f66eec34e10ce3 |
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| Quellennotiz | uspto-grants-2008_09 |
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