Hydrochloric Acid → HCID 59320781, Verbindung

HRID 341225Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 341225
C([O:3][C:4](=[O:31])/[CH:5]=[CH:6]/[C:7]1[CH:12]=[CH:11][N:10]2[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]([NH:25][CH2:26][C:27]([F:30])([F:29])[F:28])=[O:24])[CH:17]=3)=[CH:14][N:15]=[C:9]2[CH:8]=1)C.C([O-])([O-])=O.[Na+].[Na+].Cl>CCO>[F:30][C:27]([F:28])([F:29])[CH2:26][NH:25][C:23](=[O:24])[NH:22][C:18]1[CH:17]=[C:16]([C:13]2[N:10]3[CH:11]=[CH:12][C:7](/[CH:6]=[CH:5]/[C:4]([OH:31])=[O:3])=[CH:8][C:9]3=[N:15][CH:14]=2)[CH:21]=[CH:20][CH:19]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 59321019HCID 59321019, Verbindung

Produkt 1

HCID 59320781HCID 59320781, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of (E)-3-(3-{3-[3-(2,2,2-Trifluoro-ethyl)-ureido]-phenyl}-imidazo[1,2-a]pyridin-7-yl)-acrylic acid ethyl ester (83 mg, 0.19 mmol) in EtOH (10 ml) was added 1M Na2CO3 (4 ml) and the reaction heated to 80° C. for 1.5 h. The reaction was neutralised using 1M HCl and then concentrated. The residue was taken up in hot EtOH, filtered and the solvent removed in vacuo to afford the product. MS: [M+H]+ 405.

Aufarbeitung

  1. concentrationconcentrated
  2. filtrationfiltered
  3. customthe solvent removed in vacuo
  4. customto afford the product

Quellen und Nachweise

ORD-Eintrag
ord-67b7425560b5433cb5002489e872b1a1
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895745B2

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