Hydrochloric Acid → HCID 25154341, Verbindung

HRID 341279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 341279
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:22])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][N:17]=1)=[O:22]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 251886012-(Acetyloxy)-N-[5-(methylsulfonyl)-2-thiazolyl]benzamide

Produkt 1

HCID 25154341HCID 25154341, VerbindungAusbeute 95,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 7 (1.0 g, 2.94 mmol, 1.0 eq) dissolved in THF (20 mL) was added under stirring to 2M HCl (100 mL). The reaction was refluxed for one hour and allowed to cool under stirring over one hour. The product was filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum to afford 834 mg (95%) of 6 as a colorless solid.

Aufarbeitung

  1. additionwas added
  2. temperatureThe reaction was refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product was filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-49b46472342d45449dddfb46848fa93f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08895752B2

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