Tert-butyl 4-(methylsulfonyloxymethyl)piperidine-1-carboxylate → HCID 57898964, Verbindung
Reaktionsgleichung
[CH3:1]S(OCC1CCN(C(OC(C)(C)C)=O)CC1)(=O)=O.C([S-])CC.[Na+].F[C:26](F)(F)[CH2:27][S:28][CH2:29][CH:30]1[CH2:35][CH2:34][N:33]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:32][CH2:31]1>>[CH3:26][CH:27]([S:28][CH2:29][CH:30]1[CH2:35][CH2:34][N:33]([C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH2:32][CH2:31]1)[CH3:1]Komponenten
4
Versuchsvorschrift
tert-Butyl 4-[(propan-2-ylsulfanyl)methyl]piperidine-1-carboxylate was prepared from tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate (Intermediate 181, 0.320 g, 1.091 mmol) and sodium propanethiolate (0.161 g, 1.636 mmol) according to the method described for Intermediate 183 to afford the title compound (0.180 g, 60%). Method B HPLC-MS: MH+ requires m/z=274 Found: m/z=218 (M-tert-Bu), Rt=2.51 min.