Ethyl trifluoroacetate → N-[2-(3-Bromophenyl)ethyl]-2,2,2-trifluoroacetamide

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Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][CH2:6][NH2:7].[F:11][C:12]([F:19])([F:18])[C:13](OCC)=[O:14]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][CH2:6][NH:7][C:13](=[O:14])[C:12]([F:19])([F:18])[F:11]

Komponenten

Edukt 2

HCID 9794Ethyl trifluoroacetate

HCID 70217363-Bromophenethylamine

Produkt 1

HCID 18414326N-[2-(3-Bromophenyl)ethyl]-2,2,2-trifluoroacetamide

Versuchsvorschrift

Condensation of 3-bromophenethylamine with ethyl trifluoroacetate gave N-(3-bromophenethyl)-2,2,2-trifluoroacetamide as a colorless oil. Yield (3.30 g, quant.). 1H NMR (400 MHz, CDCl3) δ 7.40 (ddd, J=7.8, 1.8, 1.0 Hz, 1H), 7.53 (t, J=1.8 Hz, 1H), 7.21 (t, J=7.6 Hz, 1H), 7.10-7.13 (m, 1H), 6.32 (br s, 1H), 3.61 (q, J=6.7 Hz, 2H), 2.87 (t, J=7.2 Hz, 2H).

Quellen und Nachweise

ORD-Eintrag: ord-4a99c289411c4ce1aa7353ed0199a1a3
Quelldatensatz: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08895782B2

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