Methyl iodide → 3-Iodo-4,5-dimethoxybenzaldehyde
Reaktionsgleichung
[I:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:13](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:11][O:10][C:4]1[CH:5]=[C:6]([CH:9]=[C:2]([I:1])[C:3]=1[O:12][CH3:13])[CH:7]=[O:8]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 5-iodovanillin (7 g, 25.18 mmole), potassium carbonate (8.78 g, 63.53 mmole) and iodomethane (6.43 g, 45.30 mmole) was suspended in 60 mL of DMF and stirred at room temperature for 14 hours. The reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over MgSO4, filtered and evaporated in vacuo to obtain a solid which was recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%).
Aufarbeitung
- customThe reaction mixture was quenched with water
- extractionextracted with diethyl ether
- dry with materialThe organic layer was dried over MgSO4
- filtrationfiltered
- customevaporated in vacuo
- customto obtain a solid which
- customwas recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%)
Quellen und Nachweise
- ORD-Eintrag
- ord-cf2a47a2c6ac4469ba02a0f92452f246
- Quelldatensatz
- uspto-grants-1999_01
- Patentnummer
- US05856323
Notizen zur Reaktion
Wird geladen…