3-Fluorobenzoyl chloride → HCID 15733509, Verbindung

HRID 341862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 341862
[CH3:1][N:2]([C:4]([NH:6][CH3:7])=[S:5])[NH2:3].[F:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12](Cl)=[O:13]>N1C=CC=CC=1>[CH3:1][N:2]([C:4]([NH:6][CH3:7])=[S:5])[NH:3][C:12](=[O:13])[C:11]1[CH:15]=[CH:16][CH:17]=[C:9]([F:8])[CH:10]=1

Komponenten

4

Edukt 2

HCID 743763-Fluorobenzoyl chlorideHCID 30341872,4-Dimethylthiosemicarbazide

Produkt 1

HCID 15733509HCID 15733509, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a stirred, room temperature, solution of 2,4-dimethylthiosemicarbazide (5.96 g, 50.0 mmol) and dry pyridine (100 mL) was added dropwise 3-fluorobenzoyl chloride (7.93 g, 50.0 mmol). After stirring overnight, the reaction mixture was evaporated at reduced pressure. The concentrate was slurried with water and that which did not dissolve was collected by filtration. Crystallization of this material from ethanol afforded the desired product as colorless needles, mp 202°-205° C.

Aufarbeitung

  1. customthe reaction mixture was evaporated at reduced pressure
  2. dissolutiondid not dissolve
  3. filtrationwas collected by filtration
  4. customCrystallization of this material from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-5115182a487c49d49645869cd541a055
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856350

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