Hydrochloric Acid → (6R,7R)-7-amino-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

HRID 341905

Reaktionsgleichung

Reaktionsgleichung von HRID 341905
Cl.[NH2:2][CH:3]1[C:15](=[O:16])[N:5]2[C:6]([C:12]([OH:14])=[O:13])=[C:7]([CH:10]=[O:11])[CH2:8][S:9][C@H:4]12.N1C=CC=CC=1>CO>[NH2:2][C@@H:3]1[C:15](=[O:16])[N:5]2[C@@H:4]1[S:9][CH2:8][C:7]([CH:10]=[O:11])=[C:6]2[C:12]([OH:14])=[O:13]

Komponenten

5

Edukt 3

HCID 313Hydrochloric Acid2×HCID 1049PyridineHCID 872037627-Amino-3-formyl-3-cephem-4-carboxylic acid

Produkt 1

HCID 15385898(6R,7R)-7-amino-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

2.64 g of the hydrochloride of 6-amino-1,4,5a,6-tetrahydro-3-hydroxy-1,7-dioxo-3H,7H-aceto[2,1-b]furo[3,4-d][1,3]thiazine (hydroxylactone of the hydrochloride of 7-amino-3-formyl-3-cephem-4-carboxylic acid) are dissolved in 50 ml of methanol. A solution of 0.78 g of pyridine in 10 ml of methanol is added dropwise to this solution whilst stirring and cooling with ice. The precipitated product is filtered off under nitrogen whilst excluding moisture, washed with a little methanol and dried over a drying agent in vacuo at room temperature. (6R-trans)-7-amino-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is thus obtained in the form of a light brown powder.

Aufarbeitung

  1. temperaturecooling with ice
  2. filtrationThe precipitated product is filtered off under nitrogen
  3. washwashed with a little methanol
  4. customdried over a drying agent in vacuo at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-65be74b59f924385abf637bd0ca4da83
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856474

Verknüpfte Notizen

Wird geladen…