N-Methylallylamine → (E)-allyl-[4-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-yloxy]-but-2-enyl]-methyl-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N-Methylallylamine	HCID 69391	—
Edukt	trans-1,4-Dibromo-2-butene	HCID 641245	—
Edukt	1-(4-Bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol	HCID 135980795	—
Produkt	(E)-allyl-[4-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-yloxy]-but-2-enyl]-methyl-amine	HCID 67597954	—

Reaktionsschritte

Analogously to Example 25, from 1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-ol and (E)-1,4-dibromo-2-butene and after reaction with N-allyl-methyl-amine there is obtained (E)-allyl-[4-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinolin-6-yloxy]-but-2-enyl]-methyl-amine, which is converted into the fumarate, MS: m/e 425 (M+H+, 1 Br).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05856503
Quelldatensatz	uspto-grants-1999_01
ORD ID	ord-92f1078f453840168843e77f32032a66
Quellennotiz	uspto-grants-1999_01