Benzyl Bromide → (S)-2-Phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester

HRID 342275

Reaktionsgleichung

Reaktionsgleichung von HRID 342275
C(=O)([O-])[O-].[Cs+].[Cs+].[C:7]1(=[O:26])[N:11]([C@@H:12]([CH2:16][CH2:17][CH2:18][CH2:19][OH:20])[C:13]([OH:15])=[O:14])[C:10](=[O:21])[C:9]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:8]12.[CH2:27](Br)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CN(C)C=O>[C:10]1(=[O:21])[N:11]([C@@H:12]([CH2:16][CH2:17][CH2:18][CH2:19][OH:20])[C:13]([O:15][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:14])[C:7](=[O:26])[C:8]2=[CH:25][CH:24]=[CH:23][CH:22]=[C:9]12

Komponenten

5

Edukt 3

HCID 7498Benzyl BromideHCID 10796Cesium carbonateHCID 11065730(S)-2-Phthalimido-6-hydroxyhexanoic acid

Produkt 1

HCID 13851095(S)-2-Phthalimido-6-hydroxyhexanoic acid, phenylmethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A slurry of cesium carbonate (3.819 g, 11.7 mmol.) and (S)-2-phthalimido-6-hydroxyhexanoic acid (6.00 g, 21.6 mmol.) in dimethylformamide (60 ml.) was treated with benzyl bromide (3.30 ml., 4.75 g., 27.7 mmol.). After stirring at room temperature for 2 hours, the mixture was partitioned between ethyl acetate and water. The organic extract was washed with water (twice) and brine, then dried (sodium sulfate), filtered and stripped to give an oil. The oil was flash chromatographed (Merck silica gel, 6/4-ethyl acetate/hexane) to give essentially pure product as a solid. Recrystallization from ethyl acetate/hexane gave 7.173 g. (1st crop) and 394 mg. (2nd crop) for a total of 7.567 g. of pure title product; m.p. 106°-108.5° C; [α]D =-27.5° (c=1.5, methanol). TLC (75/25 ethyl acetate/hexanes) Rf =0.43.

Aufarbeitung

  1. customthe mixture was partitioned between ethyl acetate and water
  2. extractionThe organic extract
  3. washwas washed with water (twice) and brine
  4. dry with materialdried (sodium sulfate)
  5. filtrationfiltered
  6. customto give an oil
  7. customchromatographed (Merck silica gel, 6/4-ethyl acetate/hexane)
  8. customto give essentially pure product as a solid
  9. customRecrystallization from ethyl acetate/hexane
  10. customgave 7.173 g

Quellen und Nachweise

ORD-Eintrag
ord-45b715d194a34453893bd9993ed34fe3
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05856476

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