Benzylamine → N-[3-(decyloxy)propanoyl]-D-alanine, ethyl ester

HRID 342731

Reaktionsgleichung

Reaktionsgleichung von HRID 342731
FC(F)(F)C(O)=O.[CH2:8]([O:10][C:11](=[O:15])[C@@H:12]([CH3:14])[NH2:13])[CH3:9].C(N)C1C=CC=CC=1.[CH2:24]([O:34][CH2:35][CH2:36][C:37](Cl)=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33].COCCCCCCCCCCCC(Cl)=O>>[CH2:24]([O:34][CH2:35][CH2:36][C:37]([NH:13][C@@H:12]([C:11]([O:10][CH2:8][CH3:9])=[O:15])[CH3:14])=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

Komponenten

5

Edukt 4

HCID 7504BenzylamineHCID 98814013-Decyloxypropanoyl chloride2×HCID 1961175912-Methoxydodecanoyl chloride2×HCID 88304863D-alanine ethyl ester trifluoroacetate

Produkt 1

HCID 15383029N-[3-(decyloxy)propanoyl]-D-alanine, ethyl ester

Versuchsvorschrift

The title compound is prepared by the method of Example 14 using an equivalent amount of D-alanine ethyl ester trifluoroacetate [the title product of Example 33] as a reactant insted of benzylamine, and using 3-decyloxypropanoyl chloride [the title product of Example 98] as a reactant instead of 12-methoxy-1-dodecanoyl chloride [the title product of Example 11].

Quellen und Nachweise

ORD-Eintrag
ord-651312b6f43f451e8463e18a60e3f714
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05859052

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