Methanol → HCID 13744932, Verbindung

HRID 34325Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 34325
Cl[C:2]1[C:11]([C:12]([O:14][CH2:15]C)=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)=[CH:7][CH:8]=2)[N:3]=1.[Na].[CH3:28][OH:29]>C(Cl)Cl>[CH3:28][O:29][C:2]1[C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([S:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)=[CH:7][CH:8]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 5360545SodiumHCID 13744931Ethyl 2-chloro-7-(4-methoxyphenylmethylthio)quinolin-3-carboxylate

Produkt 1

HCID 13744932HCID 13744932, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The ester from Step 3 (7.76 g) was added to a solution of sodium (920 mg) in anhydrous methanol (50 ml) and the resulting suspension was refluxed under an argon atmosphere for 75 minutes. The mixture was cooled, diluted with CH2Cl2 (200 ml), washed with water (3×50 ml) and reduced to dryness to provide the title compound, m.p. 133°-134.5°.

Aufarbeitung

  1. temperaturethe resulting suspension was refluxed under an argon atmosphere for 75 minutes
  2. temperatureThe mixture was cooled
  3. washwashed with water (3×50 ml)

Quellen und Nachweise

ORD-Eintrag
ord-9b4fcb92c3a540a2a1e2a1fe20f8ad8a
Quelldatensatz
uspto-grants-1988_08
Patentnummer
US04761425

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