Trifluoroacetic acid → HCID 178525684, Verbindung

HRID 343406Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 343406
C(OC([N:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[CH:15]/[C:16]2[CH:24]=[C:23]3[C:19]([C:20]([CH:25]4[CH2:30][CH2:29][N:28]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])[CH2:27][CH2:26]4)=[N:21][NH:22]3)=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42]>>[F:39][C:40]([F:45])([F:44])[C:41]([OH:43])=[O:42].[NH:8]1[CH2:13][CH2:12][CH:11](/[CH:14]=[CH:15]/[C:16]2[CH:24]=[C:23]3[C:19]([C:20]([CH:25]4[CH2:30][CH2:29][N:28]([CH2:31][C:32]([OH:34])=[O:33])[CH2:27][CH2:26]4)=[N:21][NH:22]3)=[CH:18][CH:17]=2)[CH2:10][CH2:9]1

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178451206HCID 178451206, Verbindung

Produkt 1

HCID 178525684HCID 178525684, VerbindungAusbeute 97 %

Versuchsvorschrift

A solution of 4-{2-[3-(1-tert-butoxycarbonylmethyl-piperidin-4-yl)-1H-indazol-6-yl]-(E)-vinyl}-piperidine-1-carboxylic acid tert-butyl ester (0.202 g, 0.385 mmol) in trifluoroacetic acid (5 ml) was stirred at 23° for 3 h. The solvent was evaporated in vacuo and the residue was triturated with ether to give the title compound as an off-white solid (0.228 g, 97%)

Aufarbeitung

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-dcad97a2095742dd8151a43acdc89e63
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05861414

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