Methyl iodide → 1-(3-Iodopropyl)-4-methoxybenzene

HRID 343478

Reaktionsgleichung

[C:1](=O)([O-])[O-].[K+].[K+].IC.[OH:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][I:19])=[CH:12][CH:11]=1>CC(C)=O>[CH3:1][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][I:19])=[CH:12][CH:11]=1

Komponenten

Reaktionsbedingungen

Temperatur: 70 °C

Versuchsvorschrift

Anhydrous potassium carbonate (4.14 g, 30.0 mmol), iodomethane (3.74 mL, 60.0 mmol), and 3-(4-hydroxyphenyl)-1-iodopropane (1.58 g, 6.0 mmol) were added to acetone (25 mL) at rt. The mixture was heated to 70° C. for 8 h. The resulting solution was gravity filtered to remove salts and the filtrate was concentrated in vacuo to afford 3-(4-methoxyphenyl)-1-iodopropane (1.22 g, 73%).

Aufarbeitung

filtrationfiltered
customto remove salts
concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-52fdc1ed687c426187b0517b962a81b0
Quelldatensatz: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05861427

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