Oxalyl chloride → 2-(3,4,5-trimethoxyphenyl)acetyl Chloride

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Combine 3,4,5-trimethoxy-phenyl-acetic acid (2.26 g, 10 mmol) and dichloromethane (50 mL). Cool to -5° C. using a ice-salt bath. Add 2 drops of dimethylformamide followed by dropwise addition of oxalyl chloride (1.74 mL, 20 mmol). after 1 hour, warm the reaction mixture to ambient temperature. After 2 hours, evaporate the reaction mixture in vacuo to give the title compound as a liquid.

Herkunft & Nachweise