Hydrochloric Acid → HCID 54321377, Verbindung

HRID 343796Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 343796
[OH-].[Na+].[Cl:3][C:4]1[C:5]([N:19](S(C)(=O)=O)[S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2.Cl>>[Cl:3][C:4]1[C:5]([NH:19][S:20]([CH3:23])(=[O:22])=[O:21])=[C:6]2[C:11](=[CH:12][C:13]=1[Cl:14])[N:10]=[C:9]([O:15][CH3:16])[C:8]([O:17][CH3:18])=[N:7]2

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54103043HCID 54103043, Verbindung

Produkt 1

HCID 54321377HCID 54321377, VerbindungAusbeute 84 %

Versuchsvorschrift

Aqueous sodium hydroxide (1M, 145 ml, 145 mmol) was added to a suspension of 6,7-dichloro-5-di(methanesulphonyl)amino-2,3-dimethoxy-quinoxaline (12.28 g, 28.6 mmol) and the mixture was stirred at room temperature for 16 hours. The resulting orange solution was treated with 2M hydrochloric acid (to pH 3) and the solid which precipitated was filtered off, washed with water and ether, and dried under reduced pressure at 80° C. to give N-(6,7-dichloro-2,3-dimethoxyquinoxalin-5-yl)methanesulphonamide (8.46 g, 84%) as a white solid, mp 225°-227° C.

Aufarbeitung

  1. customthe solid which precipitated
  2. filtrationwas filtered off
  3. washwashed with water and ether
  4. customdried under reduced pressure at 80° C.

Quellen und Nachweise

ORD-Eintrag
ord-0bde8bca09f74ff387dcb8abd6109cee
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05863917

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