Methyl pivaloylacetate → HCID 178441204, Verbindung

HRID 343840

Reaktionsgleichung

Reaktionsgleichung von HRID 343840
[CH3:1][C:2]([CH3:11])([CH3:10])[C:3](=O)[CH2:4][C:5](OC)=[O:6].C(=O)(O)O.[NH2:16][C:17]([NH2:19])=[NH:18]>C(O)C>[NH2:19][C:17]1[N:18]=[C:5]([OH:6])[CH:4]=[C:3]([C:2]([CH3:11])([CH3:10])[CH3:1])[N:16]=1

Komponenten

4

Edukt 2

HCID 99597Methyl pivaloylacetateHCID 286947Carbonic acid-guanidine (1:1)

Produkt 1

HCID 178441204HCID 178441204, VerbindungAusbeute 75,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Methyl 4,4-dimethyl-3-oxopentanoate (15.82 g) and guanidine carbonate (20.0 g) were mixed in 80 mL of ethanol, and the solution refluxed for 16 hours. The reaction mixture was concentrated to 50 mL by removal of solvent under reduced pressure, and 20 mL of water was added. The remaining mixture was acidified to pH 5 with acetic acid, affording a white precipitate. The precipitate was collected by filtration, washed with water, and dried in a vacuum oven to give 2-amino-4-hydroxy-6-tert-butylpyrimidine (12.6 g), m.p. 285°-288° C. (dec.).

Aufarbeitung

  1. temperaturethe solution refluxed for 16 hours
  2. concentrationThe reaction mixture was concentrated to 50 mL by removal of solvent under reduced pressure, and 20 mL of water
  3. additionwas added
  4. customaffording a white precipitate
  5. filtrationThe precipitate was collected by filtration
  6. washwashed with water
  7. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-41ecf0530ced484888ca1ad68fb127f4
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05863924

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