Nitric Acid → HCID 54388458, Verbindung

HRID 343951

Reaktionsgleichung

Reaktionsgleichung von HRID 343951
[NH2:1][CH:2]([C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[C:8]([OH:13])[CH:7]=1)[C:3]([OH:5])=[O:4].[N+:14]([O-])([OH:16])=[O:15].[OH-].[Na+]>O>[NH2:1][CH:2]([C:6]1[CH:7]=[C:8]([OH:13])[CH:9]=[C:10]([OH:12])[C:11]=1[N+:14]([O-:16])=[O:15])[C:3]([OH:5])=[O:4]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 1080013,5-Dihydroxyphenylglycine

Produkt 1

HCID 54388458HCID 54388458, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

2-Amino-2-(3,5-dihydroxyphenyl)-acetic acid (183 mg, 1 mmol) was added portionwise to stirred 5.5M nitric acid (2.5 ml, 15 mmol), which has been cooled to -10° C. in an ice/salt bath. The resulting brown solution was diluted with water (2 ml), neutralised with 2M sodium hydroxide, and purified by cationic exchange chromatography (as in Example 14) to give the title compound as a fluffy yellow solid, m.p. >280° C.

Aufarbeitung

  1. custompurified by cationic exchange chromatography (as in Example 14)

Quellen und Nachweise

ORD-Eintrag
ord-d8b3701b5ba949b5bff96f29c7dfe01c
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05863947

Verknüpfte Notizen

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