Diethyl (4-chloro-2-nitroanilino)methylphosphonate → Diethyl (2-amino-4-chloroanilino)methylphosphonate

HRID 343988

Reaktionsgleichung

Reaktionsgleichung von HRID 343988
[CH2:1]([O:3][P:4]([CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[N+:18]([O-])=O)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[H][H]>C(O)C.[Pt]>[CH2:1]([O:3][P:4]([CH2:9][NH:10][C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[NH2:18])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

Komponenten

5

Edukt 2

HCID 603785Diethyl (4-chloro-2-nitroanilino)methylphosphonateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 592810Diethyl (2-amino-4-chloroanilino)methylphosphonate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of [(4-Chloro-2-nitro-phenylamino)-methyl]-phosphonic acid diethyl ester (45g, 0.139 moles) in ethanol (500 mL) was treated under nitrogen at once with 5% Platinum on carbon (1.125 g) and then hydrogenated at 30° C. until the hydrogen uptake ceased. After purging the reaction vessel with nitrogen the reaction mixture was filtered through solka floc. The filter cake was washed with ethanol (100 mL) and the filtrate was used as such for next step without purification.

Aufarbeitung

  1. customAfter purging the reaction vessel with nitrogen the reaction mixture
  2. filtrationwas filtered through solka floc
  3. washThe filter cake was washed with ethanol (100 mL)
  4. customwithout purification

Quellen und Nachweise

ORD-Eintrag
ord-31dbc0ac1def464896ff979474a6b51b
Quelldatensatz
uspto-grants-1999_01
Patentnummer
US05864040

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